Public Health.

Background: The Adult Changes in Thought (ACT) study is an ongoing population-based prospective cohort study that began in 1994 and aims to identify risk and preventive factors for dementia. ACT randomly selects and enrolls Kaiser Permanente Washington (KPWA) health plan members age ≥ 65 years. Historically, the cohort make up has been 88% non-Hispanic White participants.

Public Health.

Background: Previous studies suggest limited knowledge about Alzheimer's Disease (AD) is a barrier to underrepresented group participation in AD research. Connections between knowledge of AD and factors like social determinants of health or confidence in biomarker research have not been carefully examined. We hypothesized perceived knowledge about AD would be associated with research hesitancy independent of sociodemographics and trust of researchers.

Prevalence of risk factors of non-communicable diseases among adults in urban slums of Burdwan municipality, West Bengal: A cross sectional study.

Background & objectives Non communicable diseases (NCD) have emerged as one of the leading causes of mortality and morbidity in India in the past few decades. This study was undertaken to determine the prevalence of NCD risk factors among adults residing in urban slums of West Bengal, India. Methods A community based cross-sectional study was conducted among adult population aged 15-69 yr in urban slums of Purba Burdwan district, West Bengal over a period of two months.

Pharmacogenomic landscape of the Thai population from genome sequencing of 949 individuals.

Inter-individual variability in drug responses is significantly influenced by genetic factors, underscoring the importance of population-specific pharmacogenomic studies to optimize clinical outcomes. In this study, we analyzed whole genome sequencing data from 949 unrelated Thai individuals and conducted an in-depth analysis of 3239 genes involved in drug pharmacokinetics, pharmacodynamics, or immune-mediated adverse drug reactions. We identified 43 single nucleotide polymorphisms (SNPs), 134 diplotypes, and 15 human leukocyte antigen (HLA) alleles, all with moderate to high clinical significance.

Zinc oxide and gum tragacanth based composite hydrogel heals partial thickness burn wound by attenuating pro-inflammatory genes and enhancing regenerating growth factors.

In this study we have developed, characterized and examined the healing and regenerative potential of gum tragacanth based zinc oxide composite hydrogel (ZnO-GT). ZnO-GT composite is a pliable and soft formulation offering efficient, faster and improved burn wound healing/managements. In this procedure, we generated partial thickness burn wounds in murine model and then applied the wound with ZnO-GT formulation.