Publications by authors named "P K Roshan"
Moderating the pool of active ribosomal subunits is critical for maintaining global translation rates. A factor crucial for modulating the 60S ribosomal subunit is eukaryotic translation initiation factor-6 (eIF6). Release of eIF6 from the 60S subunit is essential to permit 60S interactions with the 40S subunit.
View Article and Find Full Text PDFModerating the pool of active ribosomal subunits is critical for maintaining global translation rates. A factor crucial for modulating the 60S ribosomal subunits is eukaryotic translation initiation factor 6. Release of eIF6 from 60S is essential to permit 60S interactions with 40S.
View Article and Find Full Text PDFErrors in chromosome segregation underlie genomic instability associated with cancers. Resolution of replication and recombination intermediates and protection of vulnerable single-stranded DNA (ssDNA) intermediates during mitotic progression requires the ssDNA binding protein Replication Protein A (RPA). However, the mechanisms that regulate RPA specifically during unperturbed mitotic progression are poorly resolved.
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- * Recent research identified eight crucial residues in the C-tail of uL14 that facilitate the interaction between eIF6 and the 60S subunit, explaining how mutations related to Shwachman-Diamond Syndrome weaken these interactions.
- * Disrupting the binding of eIF6 to the 60S complex significantly inhibits cancer cell growth, suggesting that targeting this interaction could be a promising therapeutic approach for both cancer and SDS.*