Study protocol for Adaptive ChemoTherapy for Ovarian cancer (ACTOv): a multicentre phase II randomised controlled trial to evaluate the efficacy of adaptive therapy (AT) with carboplatin, based on changes in CA125, in patients with relapsed platinum-sensitive high-grade serous or high-grade endometrioid ovarian cancer.

Introduction: Adaptive ChemoTherapy for Ovarian cancer (ACTOv) is a phase II, multicentre, randomised controlled trial, evaluating an adaptive therapy (AT) regimen with carboplatin in women with relapsed, platinum-sensitive high-grade serous or high-grade endometrioid cancer of the ovary, fallopian tube and peritoneum whose disease has progressed at least 6 months after day 1 of the last cycle of platinum-based chemotherapy. AT is a novel, evolutionarily informed approach to cancer treatment, which aims to exploit intratumoral competition between drug-sensitive and drug-resistant tumour subpopulations by modulating drug dose according to a patient's own response to the last round of treatment. ACTOv is the first clinical trial of AT in this disease setting.

Harnessing machine learning algorithms for the prediction and optimization of various properties of polylactic acid in biomedical use: a comprehensive review.

Machine learning (ML) has emerged as a transformative tool in various industries, driving advancements in key tasks like classification, regression, and clustering. In the field of chemical engineering, particularly in the creation of biomedical devices, personalization is essential for ensuring successful patient recovery and rehabilitation. Polylactic acid (PLA) is a material with promising potential for applications like tissue engineering, orthopedic implants, drug delivery systems, and cardiovascular stents due to its biocompatibility and biodegradability.

Understanding the Formation Dynamics and Physical Properties of Nanocapsules Using Charge Detection Mass Spectrometry.

Characterizing the size, structure, and composition of nanoparticles is vital in predicting and understanding their macroscopic properties. In this work, charge detection mass spectrometry (CDMS) was used to analyze nanocapsules (∼10-200 MDa) consisting of a liquid oleic acid core surrounded by a dense silica outer shell. CDMS is an emerging method for nanoparticle analysis that can rapidly measure the mass and charge of thousands of individual nanoparticles.