Fractional optimal control strategies for hepatitis B virus infection with cost-effectiveness analysis.

Hepatitis B disease is a communicable disease that is caused by the hepatitis B virus and has become a significant health problem in the world. It is a contagious disease that is transmittable from person to person either horizontally or vertically. This current study is aimed at sensitivity analysis and optimal control strategies for a fractional hepatitis B epidemic model with a saturated incidence rate in the sense of the Caputo order fractional derivative approach.

Optimal Combinations of Control Strategies and Cost-Effectiveness Analysis of Dynamics of Endemic Malaria Transmission Model.

In this study, we propose and analyze a determinastic nonlinear system of ordinary differential equation model for endemic malaria disease transmission and optimal combinations of control strategies with cost effective analysis. Basic properties of the model, existence of disease-free and endemic equilibrium points, and basic reproduction number of the model are derived and analyzed. From this analysis, we conclude that if the basic reproduction number is less than unity, then the disease-free equilibrium point is both locally and globally asymptotically stable.

Non-linear dose response of DNA double strand breaks in response to chronic low dose radiation in individuals from high level natural radiation areas of Kerala coast.

Background: The human population living in high level natural radiation areas (HLNRAs) of Kerala coast provide unique opportunities to study the biological effects of low dose and low dose rate ionizing radiation below 100 mGy. The level of radiation in this area varies from < 1.0 to 45 mGy/year.

Assessment of safety and adverse drug reactions of COVID vaccination in the South Indian population: An observational prospective cross-sectional study.

Background: COVID vaccination is now offering a way to transit out of this phase of the pandemic. Two vaccines were approved by the Central Drugs Standard Control Organization (CDSCO) in India: Covishield and Covaxin. However, the vaccines are known to have Adverse Drug Reactions (ADRs) like fever, body pains, headache, pain, and swelling at the injection site.

Evaluation of the influence of chronic low-dose radiation on DNA repair gene polymorphisms [, , ] in individuals from normal and high level natural radiation areas of Kerala Coast.

Single Nucleotide Polymorphisms (SNPs) at DNA repair genes are considered as potential biomarkers of radio-sensitivity. The coastal belt of Kerala in south west India has a patchy distribution of monazite in its beach sand that contains Th-232 and its decay products. Thus, radiation levels in this area vary from <1.