Publications by authors named "P K McNulty"
Direct measurement of neural activity in freely moving animals is essential for understanding how the brain controls and represents behaviors. Genetically encoded calcium indicators report neural activity as changes in fluorescence intensity, but brain motion confounds quantitative measurement of fluorescence. Translation, rotation, and deformation of the brain and the movements of intervening scattering or auto-fluorescent tissue all alter the amount of fluorescent light captured by a microscope.
View Article and Find Full Text PDFThere is high demand for specialist mental health services for children and young people in the UK. Non-mental health nurses are well-placed to assess the mental health needs and risks of children and young people to maximise opportunities for early intervention and relieve the pressure on child and adolescent mental health services. This article provides an overview of a service development project to develop a web-based application (app) to support non-mental health nurses when assessing the mental health needs and risks of children and young people.
View Article and Find Full Text PDFTo understand how neural activity encodes and coordinates behavior, it is desirable to record multi-neuronal activity in freely behaving animals. Imaging in unrestrained animals is challenging, especially for those, like larval , whose brains are deformed by body motion. A previously demonstrated two-photon tracking microscope recorded from individual neurons in freely crawling larvae but faced limits in multi-neuronal recording.
View Article and Find Full Text PDFBackground: The Symptoms of Infection with Coronavirus-19 (SIC) is a 30-item patient-reported outcome (PRO) measure scored by body system composites to assess signs/symptoms of coronavirus disease 2019 (COVID-19). In addition to cross-sectional and longitudinal psychometric evaluations, qualitative exit interviews were conducted to support the content validity of the SIC.
Methods: In a cross-sectional study, adults diagnosed with COVID-19 in the United States completed the web-based SIC and additional PRO measures.
Article Synopsis
- Upper-limb motor impairment after stroke is common, but evidence shows that ongoing rehabilitation can lead to significant improvements for patients in different stages of recovery.
- The study focused on 12 post-acute stroke patients who underwent two weeks of modified Constraint-Induced Movement Therapy followed by two weeks of Wii-based Movement Therapy, assessing their motor functions at multiple time points.
- Results indicated significant improvements in upper-limb function across all primary measures after each therapy program, highlighting the effectiveness of continued rehabilitation for stroke survivors, regardless of their initial level of motor function.