Innovating alopecia treatment: nanostructured lipid carriers as advanced delivery platforms.

Alopecia, a common dermatological condition, poses significant psychological and social challenges. Despite the availability of various treatments, their efficacy is often limited by poor bioavailability and delivery challenges. Nanostructured lipid carriers have emerged as promising advanced drug delivery systems for alopecia treatment due to their ability to encapsulate both hydrophilic and lipophilic compounds, enhancing their stability, solubility, and controlled release.

Ionised calcium levels during trauma resuscitation in predicting outcomes-a prospective cohort study.

Background: Haemorrhage remains the leading cause of preventable mortality following trauma, often aggravated by the acidosis, hypothermia and coagulopathy-the lethal triad of trauma. However, the impact of trauma-induced hypocalcemia on the haemorrhage remains unclear. It is intuitive to consider perturbations of ionised calcium early during trauma resuscitation in acutely injured patients given its pathophysiological significance for an improved outcome.

Phytochemical characterization and evaluation of the biological activity spectrum of ethanolic fruit extract of : a less explored plant of Ayurveda.

Objectives: (commonly known as kokum) has been employed in Ayurvedic and Siddha medicine since ancient times. Every part of the plant has its own set of advantages and applications. Therefore, the present evaluates the phytochemical composition and biological activity spectrum of the ethanolic fruit extract of

Methods: Ethanolic extract of fruits of (GIFEE) underwent TPC and TFC quantification, with bioactive components characterized GC-MS and HPLC.

Stability and Fibrillation of Lysozyme in the Mixtures of Ionic Liquids with Varying Hydrophobicity.

Combinatorial effects of small molecules provide newer avenues to improve protein stability. The combined effect of two different classes of ILs on the stability and fibrillation propensity of lysozyme (Lyz) was investigated. Imidazolium-ILs (an aromatic moiety) with varying alkyl chains, methyl (MIC), butyl (BMIC) and hexyl (HMIC), and pyrrolidinium-IL (alicyclic moiety) with butyl substitution (BPyroBr) were chosen.