The genetics of hyper IgE syndromes.

Hyper IgE syndromes (HIES) form a rare group of primary immunodeficiency disorders (PIDs) distinguished by persistent skin abscesses, dermatitis, allergies, and infections, in addition to their characteristic high serum IgE levels. Autosomal dominant (AD) and autosomal recessive (AR) genetic defects have been reported in HIES. From a clinical perspective, AD-HIES cases generally exhibit several non-immunologic features, including connective tissue, dental and skeletal abnormalities, whilst AR-HIES conditions have a higher incidence of neurologic complications and cutaneous viral infections.

Long-Term Outcomes and Survival in Patients Undergoing Multiple vs. Single Renal Artery Transplants: A Retrospective Cohort Study.

Introduction The incidence of end-stage renal disease (ESRD) is increasing, and strategies are needed to expand the available kidney donor pool. Urologists have not preferred multiple renal artery (MRA) grafts due to concerns about higher complication rates. This study aimed to compare graft and patient survival post-transplant, complications, and the time taken to reach the nadir creatinine levels.

Forging the path to precision medicine in Qatar: a public health perspective on pharmacogenomics initiatives.

Pharmacogenomics (PGx) is an important component of precision medicine that promises tailored treatment approaches based on an individual's genetic information. Exploring the initiatives in research that help to integrate PGx test into clinical setting, identifying the potential barriers and challenges as well as planning the future directions, are all important for fruitful PGx implementation in any population. Qatar serves as an exemplar case study for the Middle East, having a small native population compared to a diverse immigrant population, advanced healthcare system, national genome program, and several educational initiatives on PGx and precision medicine.