Efficacy of Dexamethasone in Reducing Postoperative Symptoms of the Surgical Extraction of Impacted Third Molars.

Introduction: Among anti-inflammatory medications, dexamethasone has an extended half-life and strong effects, particularly in oral surgical procedures. Administering dexamethasone helps reduce discomfort and inflammation and enhances recovery by minimizing postoperative complications. This study aimed to assess the effectiveness of dexamethasone administered before and after surgery in reducing postoperative pain and swelling and relieving mouth opening following the surgical removal of impacted third molars.

An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo.

Safe, effective, and low-cost oral antiviral therapies are needed to treat those at high risk for developing severe COVID-19. To that end, we performed a high-throughput screen to identify non-peptidic, non-covalent inhibitors of the SARS-CoV-2 main protease (Mpro), an essential enzyme in viral replication. NZ-804 was developed from a screening hit through iterative rounds of structure-guided medicinal chemistry.

The Impact of Socket Shield and Implant Surface Modification With Platelet-Derived Growth Factor on Osseointegration.

Implants have become the first treatment option in the anterior esthetic region. Buccal bone loss is the sequalae of tooth extraction compromising osseointegration and cosmetic goals. The present case report is of a 47-year-old female who requested to have her fractured central incisor replaced with fixed restoration supported by an implant; the tooth had already undergone a root canal and lacked a sufficient structure for crown prosthesis placement.

An Atypical Way of Restoring an Internally Mangled Implant With the Use of a Cast Post: A Case Report.

Implant-supported prostheses can lead to biological or mechanical failures. The loosening of the abutment screw and its fracture are the most common technical complications. Recovery of fractured parts is quite challenging due to the unavailability of a universal standard screw retrieval kit on the market.