Publications by authors named "P K Iablonskiĭ"
Pretransplant allosensitization to human leukocyte antigens (HLA) increases the recipient's waiting list time and mortality in lung transplantation. Rather than waiting for crossmatch-negative donors, since 2013, recipients with preformed donor-specific antiHLA antibodies (pfDSA) have been managed with repeated IgA- and IgM-enriched intravenous immunoglobulin (IgGAM) infusions, usually in combination with plasmapheresis before IgGAM and a single dose of antiCD20 antibody. This retrospective study presents our 9-year experience with patients transplanted with pfDSA.
View Article and Find Full Text PDFObjectives: Total ischaemic time (IT) is considered a limiting factor in lung transplantation. In this retrospective study, we investigate effects of IT and disease burden on outcomes after bilateral lung transplantation.
Methods: A total of 1298 patients undergoing bilateral lung transplantation between January 2010 and May 2022 (follow-up 100%, median 54 months) were included.
Article Synopsis
- - The study analyzed outcomes of first lung transplants in children under 12 compared to adolescents (12-17 years) based on patient data from 2005 to 2021.
- - Children under 12 were more likely to be transplanted for severe conditions like interstitial lung disease and pulmonary hypertension, and they required longer recovery times and support compared to older teens.
- - Despite these challenges, key outcomes like graft survival and mortality rates were similar between both age groups, indicating that younger children can have comparable results to older adolescents post-transplant.
Background: In non-ST-elevation myocardial infarction (NSTEMI) there is no consensus regarding optimal time point for coronary artery bypass grafting (CABG). Recent findings suggest that long-term outcomes are improved in early-revascularized NSTEMI patients. However, it has been stated that early surgery is associated to increased operative risk.
View Article and Find Full Text PDFObjectives: The objective of this study was to evaluate surgical handling, in vivo hemodynamic performance and morphological characteristics of decellularized mitral valves (DMVs) in a long-term sheep model.
Methods: Ovine mitral valves were decellularized using detergents and β-mercaptoethanol. Orthotopic implantations were performed in 6-month-old sheep (41.