Publications by authors named "P K Buddhika Mahesh"
Paleoneurology reconstructs the evolutionary history of nervous systems through direct observations from the fossil record and comparative data from extant species. Although this approach can provide direct evidence of phylogenetic links among species, it is constrained by the availability and quality of data that can be gleaned from the fossil record. Here, we sought to translate brain component relationships in a sample of extant Carnivora to make inferences about brain structure in fossil species.
View Article and Find Full Text PDFThin-section CT (TSCT) is currently the most sensitive imaging modality for detecting bronchiectasis. However, conventional TSCT or HRCT may overlook subtle lung involvement such as alveolar and interstitial changes. Artificial Intelligence (AI)-based analysis offers the potential to identify novel information on lung parenchymal involvement that is not easily detectable with traditional imaging techniques.
View Article and Find Full Text PDFIncidence of liver cancer as one of the most common cancers worldwide and become the significant contributor for the mortality among cancer patients. The disease burden, risk factors, and trends in incidence and mortality of liver cancer globally was described subsequently estimated the projections of liver cancer incidence or mortality by 2040. Data regarding age-standardized incidence and mortality rates for liver cancer was obtained from multiple databases, including GLOBOCAN 2020, CI5 volumes I-XI, WHO mortality database, and Global Burden of Disease (GBD)-2019.
View Article and Find Full Text PDFArticle Synopsis
- Chronic Obstructive Pulmonary Disease (COPD) is a significant health issue, primarily caused by tobacco smoke and biomass smoke, with less understanding of Biomass-Smoke-Induced COPD (BSCOPD) compared to Tobacco-Smoke-Induced COPD (TSCOPD), especially in low-income areas.
- This review outlines differences in clinical features and inflammatory responses between BSCOPD and TSCOPD, noting that BSCOPD shows less emphysema, more pulmonary hypertension, and distinct airway remodeling.
- There is a call for more targeted research to improve diagnosis and treatment of BSCOPD, focusing on identifying specific biomarkers and understanding the unique biological mechanisms involved.
Article Synopsis
- * The review explores allergen immunotherapy (AIT) as the only disease-modifying treatment for IgE-mediated allergic diseases, detailing its two main forms: subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT).
- * AIT has been shown to effectively alleviate AC symptoms, reduce medication needs, and enhance quality of life, with SLIT noted for its better safety profile and overall long-term benefits.