Anticancer and Cyclooxygenase Inhibitory Activity of Benzylidene Derivatives of Fenobam and its Thio Analogues.

Introduction: A series of benzylidene derivatives of fenobam and its thio analogues (1-22) have been evaluated for their cytotoxicity against breast cancer (MCF-7, MDA-MB-231), ovarian cancer (A2780, SKOV-3) and cervical cancer (HELA) cell lines.

Method: These compounds (1-22) exhibited 72-83% inhibition of Erk activity against the ovarian cancer cell line (A2780). Compounds 3 and 20 showed the highest DNA damage effect in Comet Assay against the A2780 cancer cell line as compared to the other tested analogues (4, 8, 11, 12, and 13) by using % Tail DNA and OTM.

What is Sphenomorphus maculatus (Blyth, 1854 "1853") (Reptilia: Squamata: Scincidae)? Validating cryptic diversity and the designation of a neotype.

The Spotted Litter Skink, Sphenomorphus maculatus, initially described by Edward Blyth in 1854, lacks a taxonomic reference point, as the holotype was reported lost by 1868. A preliminary molecular phylogenetic analysis revealed indications of cryptic diversity within S. maculatus across its range in Northeast India.

Study of Glabranin as an Inhibitor Against Prostate Cancer: Molecular Docking, Molecular Dynamics Simulation, MM-PBSA Calculation and QSAR Prediction.

Unlabelled: Prostate cancer is the World's second most frequent malignancy, with the fifth-highest male mortality rate. In advanced prostate cancer patients, point mutations such as T877A and W741L are prevalent, imparting treatment resistance and hence promoting cancer development. The emergence of drug resistance in prostate cancer necessitates the development of suitable ligands to allow for stronger interactions with the receptors, which can inhibit cancer progression.

Development of a dual-spectroscopic system to rapidly measure diisopropyl methyl phosphonate (DIMP) decomposition and temperature in a reactive powder environment.

The development of systems to measure and optimize emerging energetic material performance is critical for Chemical Warfare Agent (CWA) defeat. In order to assess composite metal powder efficacy on CWA simulant defeat, this study documents a combination of two spectroscopic systems designed to monitor the decomposition of a CWA simulant and temperature rises due to combusting metal powders simultaneously. The first system is a custom benchtop Polygonal Rotating Mirror Infrared Spectrometer (PRiMIRS) incorporating a fully customizable sample cell to observe the decomposition of Diisopropyl Methyl Phosphonate (DIMP) as it interacts with combusting composite metal particles.