Interferon-driven Metabolic Reprogramming and Tumor Microenvironment Remodeling.

IFNs play a critical role in cancer biology, including impacting tumor cell behavior and instructing the tumor microenvironment (TME). IFNs recently have been shown to reprogram tumor metabolism through distinct mechanisms. Furthermore, IFNs shape the TME by modulating immune cell infiltration and function, contributing to the intricate interaction between the tumor and stromal cells.

Spousal perceptions and their role in promoting breast cancer screening: a focus group study.

Objectives: To explore husbands' views on breast cancer screening, risk-based screening and their role in influencing their wives' health-seeking behaviours.

Design: Qualitative focus group discussion (FGD) supplemented by quantitative data from a cohort study using a structured questionnaire.

Setting: This study was conducted in a community-based setting, with participants recruited online through non-profit organisations via social media and email.

All-electrical layer-spintronics in altermagnetic bilayers.

Electrical manipulation of spin-polarized current is highly desirable yet tremendously challenging in developing ultracompact spintronic device technology. Here we propose a scheme to realize the all-electrical manipulation of spin-polarized current in an altermagnetic bilayer. Such a bilayer system can host layer-spin locking, in which one layer hosts a spin-polarized current while the other layer hosts a current with opposite spin polarization.

Tissue factor pathway inhibitor levels and atherothrombotic events in patients with chronic kidney disease or diabetes.

Increased tissue factor pathway inhibitor (TFPI) has been associated with cardiovascular disease (CVD). We aim to evaluate the predictive capability of TFPI for atherothrombotic events (ATE) in patients with chronic kidney disease (CKD) and diabetes. A prospective observational study was performed at Northern Health, Australia.

Antibody reactivity against EBNA1 and GlialCAM differentiates multiple sclerosis patients from healthy controls.

Multiple sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous system (CNS), which is linked to Epstein-Barr virus (EBV) infection, preceding the disease. The molecular mechanisms underlying this connection are only partially understood. We previously described molecular mimicry between the EBV transcription factor EBV nuclear antigen 1 (EBNA1) and three human CNS proteins: anoctamin-2 (ANO2), alpha-B crystallin (CRYAB), and glial cellular adhesion molecule (GlialCAM).