Publications by authors named "P Joseph Mee"
Article Synopsis
- Australia has low pathogenicity avian influenza viruses circulating within its territory.
- A Eurasian low pathogenicity avian influenza H5 virus has recently been detected in Australia.
- This finding is important for monitoring and diagnostics, especially given the potential risk of highly pathogenic avian influenza A(H5N1) not currently being present.
Article Synopsis
- - The high pathogenicity avian influenza virus H5N1 outbreak highlights the serious threats posed by viral incursions to both wildlife and domestic animals.
- - Recent findings in Australia identified two low pathogenicity avian influenza virus subtypes, H4 and H10, with different evolutionary patterns, emphasizing the complex nature of viral spread.
- - Phylogenetic analysis shows H4 viruses from shorebirds are a new introduction from Asia, while H10 has evolved into a new lineage in various bird populations, illustrating the importance of understanding these dynamics for better disease management.
Article Synopsis
- Ross River virus (RRV) and Barmah Forest virus (BFV) are related viruses found in Australia and Papua New Guinea, showing evidence of convergent evolution in their genetic development.
- Analysis of multiple genomes revealed that specific mutations in key proteins are important for their replication and interaction with host cells, indicating similarities in how both viruses adapt to their environments.
- Although some mutations appear to have benefited their evolution, the overall selection pressures suggest that RRV and BFV have undergone purifying selection, maintaining stable functions during their replication in different hosts like mosquitoes and vertebrates.
The Australian Biosecurity Genomic Database (ABGD) is a curated collection of reference viral genome sequences based on the Australian National Notifiable Disease List of Terrestrial Animals. It was created to facilitate the screening of high-throughput sequencing (HTS) data for the potential presence of viruses associated with notifiable disease. The database includes a single verified sequence (the exemplar species sequence, where relevant) for each of the 60 virus species across 21 viral families that are associated with or cause these notifiable diseases, as recognized by the World Organisation for Animal Health.
View Article and Find Full Text PDFObjective: To identify individual-level early warning indicators of virologic failure in HIV patients receiving antiretroviral therapy (ART) in South Africa.
Design: A matched case-control study of individuals with and without virologic failure (VF) (>5 months on ART and HIV-1 plasma viral load >1,000 copies/mL) was conducted between June 2014 and June 2018. Of the 1,000 participants enrolled in the parent cohort, 96 experienced VF, and 199 additional controls were identified from the parent cohort and matched 1:2 (some matched 1:3) for sex, age, ART duration, and site.