Publications by authors named "P Joseph Cherian"
BharatSim is an open-source agent-based modelling framework for the Indian population. It can simulate populations at multiple scales, from small communities to states. BharatSim uses a synthetic population created by applying statistical methods and machine learning algorithms to survey data from multiple sources, including the Census of India, the India Human Development Survey, the National Sample Survey, and the Gridded Population of the World.
View Article and Find Full Text PDFThe Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Mannitol, Sorbitol, and Xylitol as used in cosmetics. These ingredients are reported to function as humectants, skin-conditioning agents, or flavoring agents. The Panel considered the available data and concluded that these sugar alcohol ingredients are safe in cosmetics in the present practices of use and concentration described in the safety assessment.
View Article and Find Full Text PDFToxins TcdA and TcdB are the main virulence factors of Clostridioides difficile, a leading cause of hospital-acquired diarrhea. Despite their importance, there is a significant knowledge gap of druggable targets for inhibiting toxin production. To address this, we screened nonantibiotic phytochemicals to identify potential chemical genetic probes to discover antivirulence drug targets.
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- COVID-19 poses a higher mortality risk for individuals with diabetes, severe obesity, and cardiovascular disease, potentially due to chronic inflammation linked to type 2 diabetes.
- This study involved 350 patients with type 2 diabetes hospitalized for moderate-severe COVID-19, comparing the effects of pioglitazone against a placebo over 28 days, focusing on severe clinical outcomes and inflammation levels.
- Although pioglitazone reduced certain inflammatory markers, it did not significantly improve outcomes, as more patients treated with it required ICU care and showed no notable difference in CRP reduction compared to those on placebo.
A mixed method approach was utilized to assess the organizational culture of the mental health service line at a large Veterans Affairs (VA) hospital. The goals of the study were to assess the organizational culture, identify how employees differ in perceptions of organizational culture, and identify areas of strength and challenges. Two hundred thirteen participants returned a questionnaire assessing perceptions of organizational culture using the Organizational Culture Assessment Questionnaire (Sashkin & Rosenbach, 2013).
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