Publications by authors named "P Jonkheijm"
Particles are essential building blocks in nanomedicine and cell engineering. Their administration often involves blood contact, which demands a hemocompatible material profile. Coating particles with isolated cell membranes is a common strategy to improve hemocompatibility, but this solution is nonscalable and potentially immunogenic.
View Article and Find Full Text PDFIntravascular surgical instruments require precise navigation within narrow vessels, necessitating maximum flexibility, minimal diameter, and high degrees of freedom. Existing tools often lack control during insertion due to undesirable bending, limiting vessel accessibility and risking tissue damage. Next-generation instruments aim to develop hemocompatible untethered devices controlled by external magnetic forces.
View Article and Find Full Text PDFHydrophobic microparticles are one of the most versatile structures in drug delivery and tissue engineering. These constructs offer a protective environment for hydrophobic or water-sensitive compounds (e.g.
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- Detecting circulating tumor cells (CTCs) is tough because they are present in low numbers and vary in characteristics, with traditional methods struggling for those with low EpCAM expression.
- This study introduces a new approach using silica-coated magnetic nanobeads with streptavidin for better CTC capture.
- The new method showed higher capture rates for specific cancer cell lines, especially those with low EpCAM expression, indicating its potential for improving CTC detection compared to existing commercial options.
Article Synopsis
- Blood shortages are a significant global issue impacting healthcare, prompting research into blood substitutes like hemoglobin-based carriers and perfluorocarbons, though widespread solutions remain elusive due to safety and scalability challenges.
- This review focuses on advances in creating artificial red blood cells, categorizing strategies as natural, synthetic, or hybrid, and highlights synthetic engineered erythrocytes as the most promising approach.
- The article examines the biological design and functions of these synthetic cells, exploring their size, shape, deformability, and potential applications in medicine while suggesting future directions for erythrocyte engineering.