Publications by authors named "P Johnsson"

Article Synopsis
  • COVID-19 is a critical respiratory illness impacting many people globally, and the hormone adrenomedullin (bio-ADM) plays a role in predicting mortality and severity in infected patients.
  • A study of 119 patients in Southern Sweden analyzed bio-ADM levels at ICU admission, day 2, and day 7, focusing on its correlation with 90-day mortality and adverse events.
  • Results showed that while bio-ADM levels moderately predicted mortality, the relative change in bio-ADM levels over time was a better indicator of outcomes, suggesting its potential use for patient triage and treatment strategies.
View Article and Find Full Text PDF

Pharmacokinetics (PK) of antisense oligonucleotides (ASOs) is characterized by rapid distribution from plasma to tissue and slow terminal plasma elimination driven by re-distribution from tissue. Quantitative understanding of tissue PK and RNA knockdown for various ASO chemistries, conjugations, and administration routes is critical for successful drug discovery. Here, we report concentration-time and RNA knockdown profiles for a gapmer ASO with locked nucleic acid ribose chemistry in mouse liver, kidney, heart, and lung after subcutaneous and intratracheal administration.

View Article and Find Full Text PDF

The unique Swecrit Biobank and its associated clinical registries for sepsis, ARDS, cardiac arrest, trauma, and COVID-19 include more than 150,000 blood samples and descriptions of critically ill patients. These assets provide a unique opportunity to research and improve the care of the most seriously ill patients through biomarker analyses, proteomic studies, and genetic and epigenetic studies using modern machine learning techniques (artificial intelligence). Interested researchers are invited to submit their proposals and participate.

View Article and Find Full Text PDF

Background: Sepsis is common in the intensive care unit (ICU). Two of the ICU's most widely used mortality prediction models are the Simplified Acute Physiology Score 3 (SAPS-3) and the Sequential Organ Failure Assessment (SOFA) score. We aimed to assess the mortality prediction performance of SAPS-3 and SOFA upon ICU admission for sepsis and find a simpler mortality prediction model for these patients to be used in clinical practice and when conducting studies.

View Article and Find Full Text PDF

Stress-related health problems have increased sharply over the last two decades and have become a serious issue at all levels of society. In the Jönköping Region in southern Sweden, a nature-based rehabilitation (NBR) program for adults with Exhaustion Syndrome has been developed and then implemented into the Swedish National Healthcare System. The main aim of this study was to investigate the effectiveness of this NBR-program.

View Article and Find Full Text PDF