Publications by authors named "P Jittamala"
Background: Parenteral artesunate is the first-line therapy for severe malaria. Artesunate, in its current formulation, must be prepared immediately before administration by first dissolving in sodium bicarbonate solution and then diluting in saline. A novel solvent for rapid and stable single step reconstitution of artesunate was recently developed showing improved solubility and stability.
View Article and Find Full Text PDFIn preparation for mass vaccinations with R21/Matrix-M™ combined with mass administrations of dihydroartemisinin, piperaquine, and a single low dose primaquine we assessed the tolerability, safety, and potential interactions of this combination affecting immunogenicity or pharmacokinetics. 120 healthy Thai volunteers were randomised to receive either antimalarials combined with vaccinations (n = 50), vaccinations alone (n = 50), or antimalarials only (n = 20). Three rounds of vaccines and antimalarials were administered one month apart.
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- Ivermectin is a medicine that can help control mosquitoes and could be useful in fighting malaria.
- The study looked at two types of ivermectin (B and B) to see if they are equally effective at killing certain kinds of mosquitoes.
- The results showed that both types of ivermectin were equally effective, and the amounts of each type in different products were very similar.
Article Synopsis
- Antiviral drugs are crucial in preventing severe outcomes from COVID-19, and measuring the clearance of SARS-CoV-2 in patients helps assess their effectiveness.
- A meta-analysis of data from the PLATCOV trial focused on how viral clearance rates change over time in patients to improve the design of future antiviral drug evaluations.
- The study found that effective antiviral interventions speed up the initial phase of viral clearance, with the best results observed within the first five days after treatment begins.