Transcatheter mitral valve replacement to treat rheumatic mitral stenosis: a case series.

Background: Rheumatic mitral stenosis (RMS) is a common valvular heart disease in developing countries. We sought to evaluate the early experience of patients with RMS undergoing transcatheter mitral valve replacement (TMVR).

Methods: In this retrospective study, a total of 5 RMS patients accepted TMVR.

The Application of a New Framework Construction Technique in Autologous Costal Cartilage Rhinoplasty.

Background: In this study, the clinical efficacy of a new framework construction technique for costal cartilage rhinoplasty was investigated.

Methods: From January 2020 to February 2022, patients who underwent rhinoplasty in the department of plastic and reconstructive surgery of Zhejiang Provincial People's Hospital were enrolled. The sixth costal cartilage was made into the nasal columellar support graft (strut), the nasal tip graft integrated scaffold, and the septal extension grafts.

Glycosyltransferase-Mediated Modulation of Reactive Oxygen Species Enhances Non-host Resistance to Pst DC3000 in Nicotiana benthamiana.

Non-host resistance (NHR) governs defense responses against a broad range of potential pathogen species in contrast with host resistance. To identify specific genes involved in disease resistance, we used a virus-induced gene-silencing screen in Nicotiana benthamiana and identified glycosyltransferase (NbGT) as an essential component of NHR. NbGT silencing enhanced the hypersensitivity response, reactive oxygen species response, and callose deposition in N.

[Enzymatic reaction pattern of saponins in Gynostemma pentaphyllum and identification of their transformed products].

The activity of rare saponins is generally better than that of their prototypes. There are significant differences in the proportions and pharmacological effects of rare saponins/prototype saponins in Gynostemma pentaphyllum samples dried with different methods, which may be related to the reaction catalyzed by glucosidase. To explore the pattern of the enzymatic reaction catalyzed by glucosidase during the processing of G.

NF-κB/Relish readjusts miR-100 expression and recovers immune homeostasis in Drosophila melanogaster.

The regulation and maintenance of immune homeostasis are essential for animal survival, but the molecular mechanisms are not fully understood. Here, we used the model organism Drosophila melanogaster to uncover a potential mechanism by which the nuclear factor-κB transcription factor Relish and miR-100 cooperatively regulate innate immune homeostasis. We first demonstrated in vitro and in vivo that miR-100 can negatively regulate the immune responses of the Imd pathway by inhibiting the expression of TAK1-associated binding protein 2 (Tab2) gene.