Publications by authors named "P Jenoe"
The Descemet's membrane (DM) and the lens capsule (LC) are two ocular basement membranes (BMs) that are essential in maintaining stability and structure of the cornea and lens. In this study, we investigated the proteomes and biomechanical properties of these two materials to uncover common and unique properties. We also screened for possible protein changes during diabetes.
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- The study investigates the potential of tear protein biomarkers to diagnose and predict the severity of ocular graft-versus-host disease (oGVHD) in patients who have undergone allogeneic hematopoietic cell transplantation (AHCT).
- Researchers analyzed tear samples from 49 patients of varying oGVHD severity grades using advanced mass spectrometry and developed predictive models to classify disease severity.
- Results showed high accuracy in differentiating disease grades with a specific focus on a 13-marker protein panel that could possibly forecast progression to more severe forms of oGVHD.
Previous studies in model eukaryotes have demonstrated that phosphorylation of heterochromatin protein 1 (HP1) is important for dynamically regulating its various functions. However, in the malaria parasite Plasmodium falciparum both the function of HP1 phosphorylation and the identity of the protein kinases targeting HP1 are still elusive. In order to functionally analyze phosphorylation of P.
View Article and Find Full Text PDFBackground: Cerebral small vessel disease (SVD) is an important cause of stroke and vascular cognitive impairment (VCI), leading to subcortical ischemic vascular dementia. As a hereditary form of SVD with early onset, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) represents a pure form of SVD and may thus serve as a model disease for SVD. To date, underlying molecular mechanisms linking vascular pathology and subsequent neuronal damage in SVD are incompletely understood.
View Article and Find Full Text PDFPurpose: To date, no biomarkers for ocular graft versus host disease (GvHD), a frequent complication following allogeneic hematopoietic cell transplantation (HCT), exist. In this prospective study, we evaluated the potential of human tear proteins as biomarkers for ocular GvHD.
Methods: Tears from 10 patients with moderate-to-severe ocular GvHD were compared to 10 patients without ocular GvHD.