Publications by authors named "P Jego"
Heart and systemic sclerosis-findings from a national cohort study.
Rheumatology (Oxford)
November 2023
Objectives: Heart involvement is one of the leading causes of death in systemic sclerosis (SSc). The prevalence of SSc-related cardiac involvement is poorly known. Our objective was to investigate the prevalence and prognosis burden of different heart diseases in a nationwide cohort of patients with SSc.
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- A study was conducted to investigate the characteristics and outcomes of ANCA-associated vasculitis (AAV) caused by anti-thyroid drugs (ATDs), specifically focusing on microscopic polyangiitis (MPA).
- The research included 45 patients with ATD-induced AAV, and it was found that most had positive ANCA results, with skin complications and joint pain being the primary symptoms.
- Compared to primary MPA, ATD-induced MPA patients were younger, had more skin problems and fewer kidney issues, and experienced a lower risk of disease relapse after treatment.
Article Synopsis
- A study compared two ways of giving a medicine called tocilizumab to patients with a disease called Takayasu arteritis (TAK).
- They looked at 109 patients from different countries and found that both methods worked similarly well after 6 months, with about 69% showing improvement.
- However, patients who got tocilizumab as a shot under the skin had a higher chance of getting worse again compared to those who received it through an IV.
Article Synopsis
- Pulmonary arterial hypertension (PAH) is a significant health issue in mixed connective tissue disease (MCTD), with a notable impact on survival rates among affected patients.
- Risk factors identified for PAH in MCTD include pericarditis, polyarthritis, thrombocytopenia, interstitial lung disease, and anti-Sm antibodies.
- Additionally, tobacco exposure has been linked to higher mortality rates in MCTD patients diagnosed with PAH.
Article Synopsis
- The authors find the findings from Marketos et al. intriguing, particularly about the presence of certain auto-antibodies in patients with sicca symptoms.
- They suggest that these scleroderma-related antibodies may indicate a link between scleroderma and Sjogren's syndrome rather than just pointing towards Sjogren's alone.
- The authors believe that these antibodies could signal undiagnosed scleroderma, emphasizing the need for further investigation.