Histological Study of Skin Structures From Selected Body Areas in the Varanus komodoensis.

The skin of the Komodo dragon (Varanus komodoensis) is covered by a form of armour formed mainly of scales, which often co-occur with osteoderms. Scales are keratinized, non-mineralized structures in the uppermost layer of the epidermis that are in contact with each other to form a system in which individual scales are isolated from each other by a softer skin fold zone. In the Varanus, the surface of the scales is flat and smooth (thoracic limb, abdomen, and tail areas), domed and smooth (head area) or domed with conical ornamentation (dorsal surface, pelvic limb-dorsal surface areas).

Mosquitoes (Diptera: Culicidae) of Poland: An Update of Species Diversity and Current Challenges.

This article presents the current state of knowledge of mosquito species (Diptera: Culicidae) occurring in Poland. In comparison to the most recently published checklists (1999 and 2007), which listed 47 mosquito species, four species (, , , and ) are added to the Polish fauna. Our new checklist of Polish mosquito fauna includes 51 species of mosquitoes from five genera: (30), (8), (1), (7), and (5).

New Schiff bases derived from dimethylpyridine-1,2,4-triazole hybrid as cytotoxic agents targeting gastrointestinal cancers: Design, synthesis, biological evaluation and molecular docking studies.

In this research, a series of novel hybrid structures of dimethylpyridine-1,2,4-triazole Schiff bases were designed, synthesized, and evaluated for their in vitro cytotoxic potency on several human gastrointestinal cancer cells (EPG, Caco-2, LoVo, LoVo/Dx, HT29) and normal colonic epithelial cells (CCD 841 CoN). Schiff base 4h was the most potent compound against gastric EPG cancer cells (CC = 12.10 ± 3.

Synthesis, Biological, Spectroscopic and Computational Investigations of Novel -Acylhydrazone Derivatives of Pyrrolo[3,4-]pyridazinone as Dual COX/LOX Inhibitors.

Secure and efficient treatment of diverse pain and inflammatory disorders is continually challenging. Although NSAIDs and other painkillers are well-known and commonly available, they are sometimes insufficient and can cause dangerous adverse effects. As yet reported, derivatives of pyrrolo[3,4-]pyridazinone are potent COX-2 inhibitors with a COX-2/COX-1 selectivity index better than meloxicam.

Imatinib-Functionalized Galactose Hydrogels Loaded with Nanohydroxyapatite as a Drug Delivery System for Osteosarcoma: In Vitro Studies.

This study reports an impact of structure (XRPD, FT-IR) and surface morphology (SEM-EDS) of imatinib-functionalized galactose hydrogels, loaded and unloaded with nHAp, on osteosarcoma cell (Saos-2 and U-2OS) viability, levels of free oxygen radicals, and nitric oxide, levels of BCL-2, p53, and caspase 3 and 9, as well as glycoprotein-P activity. It was investigated how the rough surface of the crystalline hydroxyapatite-modified hydrogel affected amorphous imatinib (IM) release. The imatinib drug effect on cell cultures has been demonstrated in different forms of administration-directly to the culture or the hydrogels.