Ru(II)-Catalysed Highly Regioselective C6 C-H/N-H Annulation of Indole-7-carboxamides with Alkynes for the Synthesis of Pyrrolo[3,2-h]isoquinolin-9-ones.

We disclosed an efficient protocol for regioselective C6 C-H/N-H activation/annulation reaction of indole-7-carboxamides with alkynes to synthesize highly substituted pyrrolo[3,2-h]isoquinolin-9-one derivatives. Under optimized reaction conditions, electron-deficient and electron-rich internal alkynes reacted efficiently with various indole-7-carboxamides to deliver desired products in good to excellent yields. The synthetic utility of the product is demonstrated by its selective oxidation to the corresponding isatin derivative.

Pregabalin for chronic cough due to lung cancer: randomized, double-blind, placebo-controlled trial.

Background: Developing effective therapies for cough in lung cancer is an unmet need Neuromodulators like pregabalin may act centrally as cough suppressants.

Methods: Randomized double-blind placebo-controlled study in patients with locally advanced/metastatic lung cancer and at least 2 weeks of moderate or severe cough. Randomization was 1:1 to pregabalin 300 mg orally daily or matching placebo, both administered for 9 weeks.

Antibiotic Management After Neonatal Enteric Operations in US Children's Hospitals.

Background: There are few evidence-based guidelines for perioperative antibiotic management in neonates who undergo enteric operations. We sought to assess antibiotic administration practices in a large population of patients who underwent operations involving enteric anastomoses and evaluate the incidence of postoperative infection and other outcomes based on antibiotic approach.

Methods: The Pediatric Health Information Systems database was queried for patients who underwent repair of esophageal, duodenal or jejuno-ileal atresia in 2021.

Structure-Based Design of Covalent SARS-CoV-2 Papain-like Protease Inhibitors.

The COVID-19 pandemic is caused by SARS-CoV-2, a highly transmissible and pathogenic RNA betacoronavirus. Like other RNA viruses, SARS-CoV-2 continues to evolve with or without drug selection pressure, and many variants have emerged since the beginning of the pandemic. The papain-like protease, PL, is a cysteine protease that cleaves viral polyproteins as well as ubiquitin and ISG15 modifications from host proteins.