Phase II study of intraperitoneal submicron particle paclitaxel (SPP) plus IV carboplatin and paclitaxel in patients with epithelial ovarian cancersurgery.

Submicron particles (~800 nm) of paclitaxel (SPP) contain 1-2 billion molecules of pure drug that release tumoricidal levels of paclitaxel over many weeks. This study compared two dose-levels of SPP instilled into the peritoneal cavity (IP) in 200 ml of saline post-cytoreductive surgery. Eligible patients with primary (n = 6) or recurrent (n = 4) epithelial ovarian cancer who underwent complete cytoreductive surgery were enrolled to receive a single instillation of IP SPP followed by standard IV carboplatin and paclitaxel.

Pyelonephritis and bacteremia caused by Haemophilus parainfluenzae: case-report of an unusual pathogen.

We present a case of a young man with known urinary tract abnormalities who developed pyelonephritis and bacteremia caused by Haemophilus parainfluenzae. Since routine urine culture usually does not include enriched media for Haemophilus spp., the true incidence of urinary tract infections caused by H.

[Challenges in the diagnostic management of fat embolism syndrome - from divergence in clinical presentation to diagnosis].

This article discusses the diagnosis and management of two patients with cerebral fat embolism syndrome after traumatic femoral fractures. Fat embolism syndrome is a condition which is caused by fat globules in the systemic circulation; it most often occurs in patients with femoral fractures. Patients develop systemic dysfunction, particularly a triad of a petechial rash, respiratory and neurological dysfunction.

Laser-prepared and bonding-filled fissure sealing: SEM and OCT analysis of marginal and internal adaptation.

This study assessed the effect of bur or Er:YAG laser preparation on marginal and internal adaptation of conventional and extended fissure sealing (FS) with a 3-component etch-and-rinse (Optibond FL; OFL) and a 1-component self-etch (Scotchbond Universal; SB) adhesive system. Scanning electron microscope analysis was performed before and after thermocycling/occlusal load and additional optical coherence tomography evaluation was carried out for internal marginal assessment. Significant differences were observed between the groups (ANOVA, p<0.

Understanding MIH: definition, epidemiology, differential diagnosis and new treatment guidelines.

Molar-Incisor Hypomineralisation (MIH) is a congenital disease which increases in prevalence. It affects permanent first molars and, often to a lesser degree, permanent incisors with variable severity. The aetiology is unknown, but different hypotheses have been advanced.