Topical oxygen emulsion: a novel wound therapy.

Objective: To investigate the use of a topical oxygen emulsion (TOE), consisting of a supersaturated oxygen suspension using perfluorocarbon components, on second-degree burns and partial-thickness wounds.

Design: Oxygen is a required substance for various aspects of wound repair, and increased oxygen tension in a wound has been shown to stimulate phagocytosis and to reduce the incidence of wound infection. Second-degree burns and partial-thickness wounds were created on the backs of specific pathogen-free pigs.

Hyperbaric oxygen solution infused into the anterior interventricular vein at reperfusion reduces infarct size in swine.

This study was designed to test the hypothesis that raising myocardial O2 via diffusion of a hyperbaric oxygen solution (AO) administered through the anterior interventricular vein (AIV) will reduce infarct size by reducing reperfusion injury associated with reduced neutrophil activation. In three pilot open-chest swine experiments, myocardial tissue Po2 was monitored using an oxygen probe during coronary occlusion (Occl) and reperfusion (Rep). One control experiment had no AIV infusion; a second control received arterial blood drawn from the femoral artery infused into the AIV during Rep.

Injection of highly supersaturated oxygen solutions without nucleation.

It is possible to inject highly supersaturated aqueous solutions of gas through a small capillary into an aqueous environment without the formation of significant gas bubbles. Such a technique has considerable potential therapeutic value in the treatment, for example, of heart attacks and strokes. The present paper is the second in a series (see Brereton et al.

Supplemental oxygen does not synergize with intracoronary radiation for the prevention of restenosis in porcine coronary arteries.

Purpose: Recurrence of obstructive coronary arterial lesions (restenosis) after angioplasty remains a significant clinical problem. Ionizing radiation, at doses >10 Gy administered locally to the angioplasty site, has been shown to inhibit restenosis in porcine coronary arteries, but lower doses are ineffective. Methods that will allow delivery of lower doses of radiation while retaining the antirestenotic efficacy observed at the higher doses are desirable.

A new bioabsorbable intravascular stent: in vitro assessment of hemodynamic and morphometric characteristics.

Currently available intracoronary stents are permanent and their placement may be complicated by thrombosis and restenosis. We have developed a new bioresorbable stent constructed of type I collagen. This stent has a compliant tubular structure that is self expanding and carries a net negative surface charge to increase hemocompatibility.