An O-methylflavone from Artemisia afra kills non-replicating hypoxic Mycobacterium tuberculosis.

Ethnopharmacological Relevance: African wormwood (Artemisia afra Jacq. ex Willd.) has been used traditionally in southern Africa to treat illnesses causing fever and was recently shown to possess anti-tuberculosis activity.

Differential Anti-Fibrotic and Remodeling Responses of Human Dermal Fibroblasts to sp., Artemisinin, and Its Derivatives.

Fibrosis is a ubiquitous pathology, and prior studies have indicated that various artemisinin (ART) derivatives (including artesunate (AS), artemether (AM), and dihydroartemisinin (DHA)) can reduce fibrosis in vitro and in vivo. The medicinal plant L. is the natural source of ART and is widely used, especially in underdeveloped countries, to treat a variety of diseases including malaria.

A methoxylated flavone from kills .

Tuberculosis, caused by (Mtb), is a deadly and debilitating disease globally affecting millions annually. Emerging drug-resistant Mtb strains endanger the efficacy of the current combination therapies employed to treat tuberculosis; therefore, there is an urgent need to develop novel drugs to combat this disease. is used traditionally in southern Africa to treat malaria and recently has shown anti tuberculosis activity.

and Extracts Have Bactericidal Activity against in Physiologically Relevant Carbon Sources and Hypoxia.

(Mtb) is a deadly pathogen and causative agent of human tuberculosis, causing ~1.5 million deaths every year. The increasing drug resistance of this pathogen necessitates novel and improved treatment strategies.

SARS-CoV-2 omicron variants are susceptible in vitro to Artemisia annua hot water extracts.

Ethnopharmacological Relevance: Artemisia annua L. has >2000 yr of history in treating fever a symptom common to many infectious diseases including viruses. The plant is widely used as a tea infusion in many areas of the globe to thwart many infectious diseases.