Publications by authors named "P J Van Der Maas"
Article Synopsis
- Metabolomics using HILIC-MS is effective for identifying polar metabolites and aiding in biomarker discovery, but matrix effects can complicate biological analysis.
- Evaluation of matrix effects is critical in method development, and this study tested two techniques: stable isotope labeled-internal standards and post-column infusion (PCI).
- Results indicated that the PCI method is more advantageous for untargeted analysis, showing better performance in assessing matrix effects and highlighting significant ion suppression in various plasma samples.
The activation of the growth hormone receptor (GHR) is a major determinant of body growth. Defective GHR signaling, as seen in human Laron dwarfism, resulted in low plasma IGF-1 concentrations and limited growth, but also marked absence in the development of breast cancer and type 2 diabetes. In vitro, we identified a small molecule (C#1) that inhibits the translation of GHR mRNA to receptor protein.
View Article and Find Full Text PDFIn the search for new antitubercular compounds, we leveraged target-directed dynamic combinatorial chemistry (tdDCC) as an efficient hit-identification method. In tdDCC, the target selects its own binders from a dynamic library generated , reducing the number of compounds that require synthesis and evaluation. We combined a total of 12 hydrazides and six aldehydes to generate 72 structurally diverse -acylhydrazones.
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- The study evaluated the long-term effectiveness and safety of cryoablation for treating abdominal wall endometriosis (AWE) in 40 patients over a median follow-up of 40.5 months.
- Results showed that 80% of patients had complete symptom relief after 3 months, and pain-free survival rates were 89.2% at 36 months and 76.8% at 60 months.
- No significant adverse events were reported, highlighting that cryoablation is a safe and effective option for managing AWE symptoms.