FAecal micRobiota transplantation in primary sclerosinG chOlangitis (FARGO): study protocol for a randomised, multicentre, phase IIa, placebo-controlled trial.

Introduction: Primary sclerosing cholangitis (PSC) is the classical hepatobiliary manifestation of inflammatory bowel disease (IBD). The strong association between gut and liver inflammation has driven several pathogenic hypotheses to which the intestinal microbiome is proposed to contribute. Pilot studies of faecal microbiota transplantation (FMT) in PSC and IBD are demonstrated to be safe and associated with increased gut bacterial diversity.

Galactinol synthase 4 requires sulfur assimilation pathway to provide tolerance towards arsenic stress under limiting sulphur condition in Arabidopsis.

Heavy metalloid stress such as arsenic (As) toxicity and nutrient imbalance constitute a significant threat to plant productivity and development. Plants produce sulfur (S)-rich molecules like glutathione (GSH) to detoxify arsenic, but sulfur deficiency worsens its impact. Previous research identified Arabidopsis thaliana ecotypes Koz2-2 (tolerant) and Ri-0 (sensitive) under low-sulfur (LS) and As(III) stress.

Protein expression of CD44 in patients with meningioma tumors: association with clinicopathological parameters and survival.

Objective: Meningiomas are a molecularly ill-defined heterogeneous group of indolent intracranial tumors. Though, WHO grade 1 tumors are histologically benign, sometimes they transform into malignant and may be recurrent which remains always challenging to clinicians. Therefore, the current study sought to discover the clinical relevance of CD44 in meningioma patients.

Open label vancomycin in primary sclerosing cholangitis-inflammatory bowel disease: improved colonic disease activity and associations with changes in host-microbiome-metabolomic signatures.

Background: We conducted a single-arm interventional study, to explore mucosal changes associated with clinical remission under oral vancomycin (OV) treatment, in primary sclerosing cholangitis associated inflammatory bowel disease (PSC-IBD); NCT05376228.

Method: Fifteen patients with PSC and active colitis (median faecal calprotectin 459µg/g; median total Mayo score 5) were treated with OV (125mg QID) for 4 weeks and followed-up for a further 4 weeks of treatment withdrawal (8 weeks, end-of-study). Colonic biopsies were obtained at baseline and week 4.

Isolation of 5-hydroxy-7-methoxy-8-O-β-D-glucopyranosyl-2S-flavanone from a new source, : characterization and anticancer activity.

This study explores the anticancer properties of , a plant indigenous to the Western Ghats of India. We isolated and characterised 5-hydroxy-7-methoxy-8-O-β-D-glucopyranosyl-2S-flavanone from , previously unreported in this plant, using preparative HPLC, NMR, and HRMS techniques. The compound's molecular structure and purity were confirmed, and its biological activity was evaluated on the MDA-MB-231 breast cancer cell line using the MTT assay.