Publications by authors named "P J Thornton"

Pastoral-agropastoral transition zones across the African continent are projected to face crop production difficulties due to climate change. A greater emphasis on livestock production may be an appropriate response in some places. Here we explore how heat stress may impact livestock productivity and human work capacity.

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Context: Congenital hyperinsulinism (CHI) is a cause of persistent hypoglycemia in childhood with considerable risk of lifelong neurological sequelae. Available pharmacological therapies are limited. Dasiglucagon is a glucagon analog for the treatment of hypoglycemia.

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Article Synopsis
  • * Researchers created a G406R knockin mouse model that exhibits TS features, including hypoglycemia, but surprisingly does not show increased beta cell activity or hyperinsulinism.
  • * The study unveils alternative mechanisms for hypoglycemia, such as impaired hormone responses and disrupted hypothalamic regulation of glucose levels, enhancing our understanding of how mutant channels impact TS.
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