Publications by authors named "P J Sanchez-Cordon"
Article Synopsis
- - The Omicron subvariants of SARS-CoV-2 are highly infectious and can evade immunity provided by initial COVID-19 vaccines, prompting interest in developing new vaccines tailored to these variants.
- - A new vaccine candidate, MVA-S(3P_BA.1), was created using a modified vaccine virus to express the spike protein from the Omicron BA.1 variant, and its effectiveness was tested in comparison to existing vaccine candidates.
- - All tested vaccines protected mice against the Omicron variant, lowering viral loads and inflammatory responses, with the new MVA-S(3P_BA.1) vaccine and a bivalent vaccine showing superior antibody production and a broader immune response to multiple variants.
Rift Valley fever (RVF) is an important zoonotic viral disease affecting several species of domestic and wild ruminants, causing major economic losses and dozens of human deaths in various geographical areas of Africa, where it is endemic. Although it is not present in Europe, there is a risk of its introduction and spread linked to globalisation and climate change. At present, the only measure that could help to prevent the disease is vaccination of flocks in areas at risk of RVF.
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- Current SARS-CoV-2 mRNA vaccines are effective, but there's a need for new strategies due to waning immunity and variant emergence, prompting this study on a heterologous mRNA/MVA vaccination approach.
- The research demonstrates that a combination of a trimeric receptor binding domain (RBD) delivered via mRNA and a modified vaccinia virus (MVA) boost creates strong immune responses, including effective antibodies and T cell activity against various SARS-CoV-2 strains.
- The heterologous regimen provided complete protection in specific mouse models after exposure to the virus, outperforming traditional methods and suggesting that alternative nanocarrier technologies could enhance vaccine effectiveness while avoiding patent issues.
Article Synopsis
- African swine fever virus (ASFV) has spread in Europe and Asia, and wild boar help spread this virus.
- Researchers studied how domestic pigs and wild boar get infected with ASFV by comparing their reactions and health over several days after infection.
- Wild boar got sick from the virus faster than domestic pigs and showed some differences in symptoms, but overall, both had limited virus spread in their noses and bottoms during early infections.