Publications by authors named "P J Saju"
Article Synopsis
- Most gastric cancers are linked to chronic infection with Helicobacter pylori strains, particularly the cagA-positive ones, and about 10% also contain the Epstein-Barr virus (EBV).
- The CagA protein from H. pylori is phosphorylated, which enhances its oncogenic activity by disrupting the normal function of the SHP2 phosphatase.
- This study identifies SHP1 as a phosphatase that can counteract CagA, and shows that EBV infection promotes hypermethylation of the SHP1 promoter, leading to lower SHP1 expression and potentially increasing gastric cancer risk.
Recent recommendations for the routine use of modified ECT prompted an audit to be undertaken to determine the incidence of musculoskeletal complications occurring in patients who received ECT at our centre from 1980 to 1990. Of the 13,597 treatments given, 98% were unmodified, due to the lack of availability of anesthetists. Musculoskeletal complications occurred in less than 1% of treatments and were of little clinical significance.
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