Publications by authors named "P J Rooney"
Article Synopsis
- Non-healing wounds lead to significant costs for the NHS, totaling over £5.6 billion annually, prompting the use of skin allografts for better infection protection.
- A study aimed to validate a new decellularisation method using Benzonase, a single enzyme, to remove DNA from donor skin, which could simplify the process compared to the current dual-enzyme approach.
- Results showed that both Benzonase and the existing method effectively removed DNA without significant differences in their performance, demonstrating Benzonase's non-toxicity and potential as a cost-effective alternative in wound treatment.
Integrating spatial inequality perspectives in strategic decision-making can ensure positive impacts on resource distribution for public welfare and sustainable development. This study aims to apply evidence-based approaches in deploying permanent deacons. The empirical case study has been conducted at the St Helens denary of the Liverpool archdiocese, UK.
View Article and Find Full Text PDFAims: To undertake a Priority Setting Partnership (PSP), identifying the most important unanswered questions in type 1 diabetes in Ireland and the United Kingdom and to compare these to priorities identified in a 2011 PSP.
Methods: A steering committee (including eight individuals with lived experience/charity representatives and six clinicians) designed a survey which asked stakeholders to list three questions about type 1 diabetes. This was disseminated through social media, direct email contact, and printed posters.
Objectives: Fresh-frozen allograft is the gold-standard bone graft material used during revision hip arthroplasty. However, new technology has been developed to manufacture decellularised bone with potentially better graft incorporation. As these grafts cost more to manufacture, the aim of this cost-effectiveness study was to estimate whether the potential health benefit of decellularised bone allograft outweighs their increased cost.
View Article and Find Full Text PDFDue to their inherent plasticity, dermal fibroblasts hold great promise in regenerative medicine. Although biological signals have been well-established as potent regulators of dermal fibroblast function, it is still unclear whether physiochemical cues can induce dermal fibroblast trans-differentiation. Herein, we evaluated the combined effect of surface topography, substrate rigidity, collagen type I coating and macromolecular crowding in human dermal fibroblast cultures.
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