Publications by authors named "P J Osborn"
It is well established that, during neural circuit development, glutamatergic synapses become strengthened via NMDA receptor (NMDAR)-dependent upregulation of AMPA receptor (AMPAR)-mediated currents. In addition, however, it is known that the neuromodulator serotonin is present throughout most regions of the vertebrate brain while synapses are forming and being shaped by activity-dependent processes. This suggests that serotonin may modulate or contribute to these processes.
View Article and Find Full Text PDFCounty-level predictors of US drug overdose mortality: A systematic review.
Drug Alcohol Depend
January 2023
Background: This systematic review summarized published literature on county-level predictors of drug overdose mortality in the United States (US).
Methods: Peer-reviewed studies and doctoral dissertations published in English between 1990 and July 19, 2022 were identified from PubMed, Web of Science, ProQuest Dissertations & Theses, PsycINFO, CINAHL, and EconLit. Eligible studies examined at least one county-level predictor of drug overdose mortality in US counties.
Innate visually guided behaviors are thought to promote survival by guiding organisms to sources of food and safety and away from harm without requiring learning. Historically, innate behaviors have been considered hard-wired and invariable, but emerging evidence shows that many innate behaviors are flexible and complex due to modulation. Here, we investigate the modulation of the innate preference for light displayed by the tadpole, an exceptionally invasive and well-studied organism that is known to display several different innate visually guided behaviors.
View Article and Find Full Text PDFArticle Synopsis
- There is growing concern about military surgeons losing critical skills for wartime medical procedures, leading to the development of the KSA Clinical Readiness Program to assess clinician readiness in the military health system (MHS).
- A revised methodology improved the assessment by focusing on key expeditionary orthopedic surgery procedures and adjusting categories and scores based on actual practices from 2017 to 2019.
- Although there was a small decrease in overall credited procedures, the revision allowed for a more accurate alignment with essential surgical skills needed during deployments.