Publications by authors named "P J Oksanen"
Recent studies have suggested that adverse outcomes of postterm birth (≥42 completed weeks of gestation), including increased cardiometabolic risk factors, impaired glucose metabolism, and obesity, may extend into adulthood. We studied interconnected determinants of cardiovascular health, including physical activity (based on accelerometry for two weeks), muscular strength (handgrip strength), cardiorespiratory fitness (4-min step test), and cardiac autonomic function (heart rate recovery, heart rate variability, and baroreflex sensitivity) among 46-year-old adults from the Northern Finland Birth Cohort (NFBC) born postterm (n = 805) and at term (n = 2,645). Adults born postterm undertook vigorous-intensity physical activity 2.
View Article and Find Full Text PDFBackground And Aims: The incidence of inflammatory bowel disease [IBD] is stabilising in many Western countries. Some still show increasing incidence. Our objective was to determine the latest trends in IBD incidence and prevalence in Finland and to compare these among different age groups and between different geographical areas.
View Article and Find Full Text PDFBackground And Aims: The early outcomes of ulcerative colitis (UC) after rescue therapy with cyclosporine A (CyA) are well known. Published data on the safety of this treatment in perioperative use and data on the long-term prognosis are scarce and are investigated here.
Methods: All UC patients treated with CyA in Tampere University Hospital between 2009 and 2018 were reviewed from patient records.
Article Synopsis
- Researchers investigated dual biological therapy (DBT) as a new treatment for patients with refractory inflammatory bowel disease (IBD), focusing on its efficacy and safety.
- The study included 16 patients, mainly with Crohn's disease, who underwent 22 trials of DBT using combinations like adalimumab and ustekinumab, with a median follow-up of nine months.
- Results showed that 32% of patients achieved remission, some experienced reduced corticosteroid reliance, and notable safety concerns included a 19% infection rate, indicating the need for further long-term studies on DBT.
Article Synopsis
- About 20% of patients with ulcerative colitis experience severe acute flare-ups, and corticosteroids are the primary treatment, but long-term efficacy data is limited.
- In a study of 217 patients treated with intravenous corticosteroids, 85% responded, but a significant number later required further treatment or colectomy.
- Only 30% of patients maintained remission six months post-treatment, suggesting a high relapse rate and the need for better maintenance therapies and monitoring.