Publications by authors named "P J O'Neill"
Aryl quinolone derivatives can target the cytochrome bc complex of Plasmodium falciparum, exhibiting excellent in vitro and in vivo antimalarial activity. However, their clinical development has been hindered due to their poor aqueous solubility profiles. In this study, a series of bioisosteres containing saturated heterocycles fused to a 4-pyridone ring were designed to replace the inherently poorly soluble quinolone core in antimalarial quinolones with the aim to reduce π-π stacking interactions in the crystal packing solid state, and a synthetic route was developed to prepare these alternative core derivatives.
View Article and Find Full Text PDFThe high incidence and mortality rates of colorectal cancer (CRC) in Alabama African Americans (AAs) and Oklahoma American Indians (AIs) are recognized as cancer disparities, yet the underlying causes have been poorly demonstrated. By evaluating CRC whole-exome sequencing and mutational profiles, here we report sets of mutated genes whose frequencies differed significantly (p < 0.05) in a race-specific manner.
View Article and Find Full Text PDFRising child welfare costs and a desire to keep kids out of the system have encouraged the use of kinship care-of which custodial grandparents make up the majority of caregivers. Unfortunately, custodial grandparents report greater needs for social and emotional support to successfully care for their grandchildren. Yet, the resources required to provide preventive social-emotional support to these families are unknown.
View Article and Find Full Text PDFBackground: Research can inform policies on substance use/substance use disorders (SU/SUDs), yet there is limited experimental investigation into strategies for optimizing policymakers' engagement with SU/SUD research. This study tested the use of narratives to boost policymakers' research engagement.
Methods: In five rapid-cycle randomized controlled trials, SU/SUD research fact sheets were emailed to US legislative policymakers.
Article Synopsis
- The fungal pathogen Zymoseptoria tritici causes significant damage to wheat crops through a disease called Septoria tritici blotch; it has a unique germination process that occurs slowly and randomly after landing on leaves.
- Research indicates that some Z. tritici spores can survive for at least 7 weeks in water, remaining virulent while adapting to low-nutrient conditions by using stored lipids and altering gene expression.
- The spores can survive even longer in soil and can be transmitted to wheat seedlings via rain-splash, highlighting the importance of understanding Z. tritici's survival mechanisms for effective disease management strategies.