Posaconazole-ibrutinib interaction cannot be avoided by staggered dosing: How to optimize ibrutinib dose during posaconazole treatment.

Aims: Ibrutinib is used in the treatment of certain B-cell malignancies. Due to its CYP3A4-mediated metabolism and highly variable pharmacokinetics, it is prone to potentially harmful drug-drug interactions.

Methods: In a randomized, placebo-controlled, three-phase crossover study, we examined the effect of the CYP3A4-inhibiting antifungal posaconazole on ibrutinib pharmacokinetics.

Performance of thin Vivacit-E hip liners: no relevant wear during ex vivo testing at high acetabular inclination angle.

Background And Purpose: There is concern among clinicians regarding the performance of thin, highly cross-linked polyethylene acetabular liners at high inclination angles that cause edge contact and high contact stresses. We studied ex vivo wear performance of thin, vitamin-E grafted, highly cross-linked polyethylene (Vivacit-E) liners in relation to high acetabular inclination angle.

Materials And Methods: Wear of Vivacit-E acetabular liners (thickness 4.

Prediction model for an early revision for dislocation after primary total hip arthroplasty.

Dislocation is one of the most common complications after primary total hip arthroplasty (THA). Several patient-related risk factors for dislocation have been reported in the previous literature, but only few prediction models for dislocation have been made. Our aim was to build a prediction model for an early (within the first 2 years) revision for dislocation after primary THA using two different statistical methods.

The COVID-19 policymaking under the auspices of parliamentary constitutional review: The case of Finland and its implications.

This article explores the dynamic interaction of emergency policies and parliamentary constitutional review in the early policy response to the COVID-19 outbreak in Finland. A thorough analysis of the official records of Parliament's Constitutional Law Committee shows how the Government's use of delegated emergency powers raised particular concerns about inter-institutional transparency during the state of emergency. These findings prompt an enquiry into whether delegated emergency powers and the related quest for centralized transparency-led accountability produced a rupture in the theory of complex multicentric policymaking.