Publications by authors named "P J Mulcahey"
Article Synopsis
- The study aimed to identify specific EEG characteristics in individuals with Rett syndrome (RTT) to determine their potential as objective indicators of brain function.
- EEG data were collected from 60 females with RTT and 26 neurotypical females, focusing on differences in brain activity and the correlation with clinical severity.
- Findings showed that RTT participants exhibited greater amplitude variability and low-frequency brain activity, with consistent patterns in EEG power measures that correlated with clinical severity, supporting the use of EEG as an objective assessment tool for RTT.
Article Synopsis
- * Researchers used advanced techniques like wide-field imaging and photo-inhibition to identify a specific brain network and a high-order motor area (MOs-c) involved in this behavior.
- * Findings suggest that corticothalamic (CT) output channels play a crucial role in enhancing action coordination and integrating sensory information from both the forelimb and face for smooth motor execution.
Article Synopsis
- CDKL5 deficiency disorder is a serious condition with no specific treatments, and the study aims to find reliable biomarkers to evaluate new therapies.
- Researchers measured brain activity through visual and auditory evoked potentials and EEG in 26 individuals with the disorder and compared their results to typically developing peers.
- The study found that people with CDKL5 deficiency had lower visual evoked potential amplitudes, and specific EEG features correlated with disease severity, especially the theta/delta ratio, which was the strongest predictor of clinical severity.
Purpose: Pharmaceutical grade cannabidiol (CBD) is one of the newest anti-seizure medications for refractory epilepsy, and the effects of CBD on EEG have not been fully described.
Methods: Patients enrolled in a CBD expanded access study had EEGs prior to and 12 weeks after initiation of CBD treatment for their refractory epilepsy. In addition to evaluating the clinical EEG reports, a nonbiased quantitative EEG (qEEG) analysis of background EEG was performed to determine whether consistent changes occur in the EEG in response to administration of CBD.
Hippocampal seizures are a defining feature of mesial temporal lobe epilepsy (MTLE). Area CA1 of the hippocampus is commonly implicated in the generation of seizures, which may occur because of the activity of endogenous cell populations or of inputs from other regions within the hippocampal formation. Simultaneously observing activity at the cellular and network scales remains challenging.
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