Publications by authors named "P J Minnick"
Purpose: To assess the safety and efficacy of AAV5-hRKp.RPGR in participants with retinitis pigmentosa GTPase regulator (RPGR)-associated X-linked retinitis pigmentosa (XLRP).
Design: Open-label, phase 1/2 dose escalation/expansion study (ClinicalTrials.
Article Synopsis
- Antibiotic resistance is a growing global health issue driven by bacterial mutations, and while drugs to combat this are underexplored, they hold promise for prolonging antibiotic effectiveness.
- Researchers identified dequalinium chloride (DEQ), an FDA-approved drug, as a potential solution that inhibits the stress response linked to increased mutagenesis when using fluoroquinolone antibiotics like ciprofloxacin.
- The study indicates that DEQ effectively slows bacterial evolution without promoting the emergence of resistant strains and shows its potential in real-world applications, such as mouse infections.
Article Synopsis
- Antibiotic resistance is a significant global health issue caused by new mutations, which can be induced by antibiotics through stress responses.
- Antibiotic-induced mutations create a subpopulation of cells in E. coli that can survive and adapt, specifically through the stringent starvation response activated by ppGpp binding to RNA polymerase.
- Understanding these mechanisms provides insights into combating resistance and opens up potential new drug targets.
The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D.
View Article and Find Full Text PDFEnteric-coated mycophenolate sodium (EC-MPS) (myfortic) is an advanced formulation delivering mycophenolic acid (MPA), designed to improve MPA-related upper gastrointestinal adverse events by delaying the release of MPA until the small intestine. A randomized, calcineurin inhibitor crossover, steady-state pharmacokinetic study in stable renal transplant patients receiving EC-MPS demonstrated increased MPA exposure of 19% higher, MPA C(max,ss) 19% lower and MPA C(min,ss) approximately twofold higher with tacrolimus, than cyclosporine microemulsion. No study drug-related adverse events were recorded, but mean blood glucose concentration was higher in patients receiving tacrolimus (p = 0.
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