Publications by authors named "P J Mattern"

Spatially resolved measurements of the argon excimer, , were performed in the effluent of a cold atmospheric plasma jet (CAPJ), the so called kINPen-sci, using cavity ringdown spectroscopy. The spatial distribution of the density of could be distinguished into two distinct populations: a Gaussian and a toroidally shaped distribution. The production mechanisms of these populations seem to differ.

View Article and Find Full Text PDF

Background: The anatomy of the hand makes it uniquely sensitive to complications after bacterial infection. The causative organism has been implicated as a predictor of complications after surgery. We hypothesize that bacterial etiology is associated with different operation and reoperation rates in patients with flexor tenosynovitis.

View Article and Find Full Text PDF

Medical gas plasma is an experimental technology for anticancer therapy. Here, partial gas ionization yielded reactive oxygen and nitrogen species, placing the technique at the heart of applied redox biomedicine. Especially with the gas plasma jet kINPen, anti-tumor efficacy was demonstrated.

View Article and Find Full Text PDF

Objectives: To determine the independent risk factors associated with increasing costs and unplanned hospital readmissions in the 90-day episode of care (EOC) for isolated operative ankle fractures at our institution.

Design: Retrospective cohort study.

Setting: Level I Trauma Center.

View Article and Find Full Text PDF

As part of a phase Ib clinical trial to determine the tolerability and safety of the highly specific acetylcholinesterase (AChE) inhibitor huperzine A, twelve (12) healthy elderly individuals received an escalating dose regimen of huperzine A (100, 200, 300, and 400 microg doses, twice daily for a week at each dose), with three (3) individuals as controls receiving a placebo. Using the WRAIR whole blood cholinesterase assay, red blood cell AChE and plasma butyrylcholinesterase (BChE) were measured in unprocessed whole blood samples from the volunteers following each dose, and then for up to 48h following the final and highest (400 microg) dose to monitor the profile of inhibition and recovery of AChE. Significant inhibition of AChE was observed, ranging from 30-40% after 100 microg to >50% at 400 microg, and peaking 1.

View Article and Find Full Text PDF