Publications by authors named "P J Mandhane"
Introduction: Throughout the perinatal period children are exposed to complex mixtures, including indoor chemicals such as phthalates, and biological agents. However, few studies focus on interactions between early-life co-exposures to shed light on how co-exposures modify their individual effects. Therefore, our study aims to assess whether early-life exposure to pets and related biological agents, namely pet allergens and endotoxin, modifies the association between di-(2-ethylhexyl) phthalate (DEHP) and asthma and wheeze in preschoolers to gain insight into interactions.
View Article and Find Full Text PDFBackground: The primary concern with prolonged hospitalization following birth is the risk of acquiring hospital-acquired infections (HAIs) caused by opportunistic bacteria, which can alter the early establishment of gut microbiota.
Objective: To assess the association between postpartum hospital length of stay (LOS) and the composition of gut microbiota at 3 and 12 months of age according to birth mode.
Methods: In total, 1313 Canadian infants from the CHILD Cohort Study were involved in this study.
Article Synopsis
- This study explored the relationship between current human milk feeding (HMF) and infant immune biomarker profiles in a cohort of 605 infants from Canada.
- Results indicated that infants currently receiving HMF had higher levels of specific immune-related biomarkers compared to those who weren't.
- The findings suggest that HMF status is important for immune development, but the duration and exclusivity of HMF did not significantly correlate with the biomarkers measured.
Article Synopsis
- * The study assesses the effects of prenatal and postnatal stress and depression on DNA methylation in newborns and 12-month-old children using the CHILD cohort, measuring stress and depression at multiple time points.
- * Results showed significant associations between both prenatal and postnatal stress/depression and changes in DNA methylation at specific CpG sites in the newborn's cord blood and in blood from 12-month-old children, suggesting a biological impact of maternal mental health on child development.
Article Synopsis
- - The CHILD Cohort Study is a long-term Canadian research project tracking the health and development of infants from pregnancy until adulthood, focusing on how early life environments affect disease outcomes like asthma and developmental issues.
- - The study involves detailed measurements and data collection including biological samples, environmental assessments, and psychosocial factors, with a strong participant retention rate over the years.
- - A sub-cohort was created during the COVID-19 pandemic to examine its impact on families, and the next major assessment phase will occur from 2022 to 2025, contributing valuable insights into chronic diseases and health complexities.