Publications by authors named "P J Lucassen"

Article Synopsis
  • Alzheimer's Disease is influenced by genetic, environmental, and lifestyle factors, including exercise, diet, education, and early life stress, which can affect its onset and progression.
  • Recent research has identified crucial biological processes, like stress hormones and neuroinflammation, that may link early life stress to an increased risk of developing Alzheimer's Disease.
  • Gaining insights into how early life experiences shape brain health could lead to new prevention and treatment strategies to counteract the impact of stress and reduce dementia risk.
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Many patients with fatigue do not visit a physician. In patients who do consult the general practitioner, the cause of their fatigue is explained in about a quarter: 8 percent has a somatic cause while psychosocial causes explain 16 percent. In about three quarters the cause of fatigue remains unexplained.

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Objectives: Persistent somatic symptoms (PSS) describe recurrent or continuously occurring symptoms such as fatigue, dizziness, or pain that have persisted for at least several months. These include single symptoms such as chronic pain, combinations of symptoms, or functional disorders such as fibromyalgia or irritable bowel syndrome. While many studies have explored stigmatisation by healthcare professionals toward people with PSS, there is a lack of validated measurement instruments.

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Purpose: Person-centered care is foundational to good quality primary care and has positive effects on health outcomes and patient satisfaction. The Person-Centered Primary Care Measure (PCPCM) is a recently developed, patient-reported survey able to assess person-centeredness and has demonstrated strong validity and reliability. Little is known, however, about the feasibility of the PCPCM in non-English-speaking settings.

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In our ageing global population, the cognitive decline associated with dementia and neurodegenerative diseases represents a major healthcare problem. To date, there are no effective treatments for age-related cognitive impairment, thus preventative strategies are urgently required. Physical exercise is gaining traction as a non-pharmacological approach to promote brain health.

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