Publications by authors named "P J Lipson"
Background Context: Endoscopic spine decompression surgery (ESDS) offers numerous benefits, including reduced tissue damage, smaller incisions, shorter recovery times, and a lower risk of complications. However, its adoption among spine surgeons in the United States has been slow. The reluctance to adopt ESDS can be attributed to factors such as the learning curve, cost of equipment and training, and limited access to necessary resources.
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- The study used mixed methods to analyze the Oswestry Disability Index (ODI) scores in people who had lumbar spine surgery versus a non-surgical group, aiming to establish threshold values for better decision-making in surgeries.
- A total of 557 patients who had surgery were compared to 797 individuals from the general U.S. population, finding that surgical patients had a significantly higher mean ODI score of 34.7 compared to 14.4 in the general population.
- The research identified a key ODI threshold of 16.5 that can help in assessing the need for spinal surgery, emphasizing that ODI scores should be part of a broader clinical evaluation rather than the sole factor in surgical decisions.
Study Design: Survey-based, prospective study.
Objective: Identify age-adjusted baseline neck disability index (NDI) values in the American population.
Background: The NDI is the most widely used tool for assessing self-rated disability in patients with neck pain.
Genetic editing of hematopoietic stem and progenitor cells can be employed to understand gene-function relationships underlying hematopoietic cell biology, leading to new therapeutic approaches to treat disease. The ability to collect, purify, and manipulate primary cells outside the body permits testing of many different gene editing approaches. RNA-guided nucleases, such as CRISPR, have revolutionized gene editing based simply on Watson-Crick base-pairing, employed to direct activity to specific genomic loci.
View Article and Find Full Text PDFBackground: Limited information is available about the prevalence of hepatitis C virus in patients with human immunodeficiency virus in relation to specific risk factors or about the influence of hepatitis C virus coinfection on survival. This retrospective study addressed these questions.
Methods: The study population consisted of 512 predominantly non-intravenous drug-using male homosexuals, 224 of whom had AIDS.