Publications by authors named "P J Lillie"
Background: High consequence infectious diseases (HCID) include contact-transmissible viral haemorrhagic fevers and airborne-transmissible infections such as Middle Eastern Respiratory Syndrome. Assessing suspected HCID cases requires specialised infection control measures including patient isolation, personal protective equipment (PPE), and decontamination. There is need for an accessible course for NHS staff to improve confidence and competence in using HCID PPE outside specialist HCID centres.
View Article and Find Full Text PDFBackground: People who inject drugs (PWID) have high rates of bloodstream infections (BSI) with Staphylococcus aureus (SA) and group A streptococcus (GAS). Little is known about health-related quality of life outcomes after BSI.
Methods: We performed a prospective pilot cohort study of patients with BSI due to SA or GAS.
Background: Infectious diseases are a major cause of mortality in spite of existing public health, anti-microbial and vaccine interventions. We aimed to define plasma proteomic associates of infection mortality and then apply Mendelian randomisation (MR) to yield biomarkers that may be causally associated.
Methods: We used UK Biobank plasma proteomic data to associate 2923 plasma proteins with infection mortality before 31st December 2019 (240 events in 52,520 participants).
Article Synopsis
- Acute leukaemias (AL) are severe blood cancers that can be treated with intensive chemotherapy, but this also increases the risk of serious infections, particularly invasive fungal infections (IFIs), due to low white blood cell counts (neutropenia).
- Current guidelines suggest using antifungal agents as a preventive measure in high-risk patients, but there's a significant issue of overprescribing these medications. Biomarkers like galactomannan and β-D-glucan could improve the diagnosis of IFIs when used together rather than separately.
- The BioDriveAFS study is a large clinical trial involving 404 participants that will compare a biomarker-based antifungal management strategy to traditional antifungal prophyl
Article Synopsis
- The study investigated the safety and effectiveness of omicron BA.1 monovalent and bivalent booster vaccines compared to the original mRNA-1273 vaccine in a large, randomized trial involving participants aged 16 and older.
- Conducted in the UK, the trial assessed antibody responses and safety profiles, focusing on the immune response at day 29 after administration of the boosters.
- A total of 3,098 participants were enrolled, with results showing differing immune responses between the new omicron boosters and the original vaccine, aiming for both non-inferiority and potential superiority.