Publications by authors named "P J Kuhlencordt"

With the recent approval of the fourth direct non vitamin K dependent oral anticoagulant (NOAC) edoxaban the range of available NOACs for the treatment of venous thromboembolism (VTE) has expanded. Shortly thereafter, two updated guidelines for the prevention and treatment of VTE have been published. In these NOACs are listed as equal anticoagulants to low-molecular weight heparin (LMWH), or fondaparinux (FDX), and VKA for the initial or maintenance treatment of VTE.

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Descending iliofemoral thrombosis in children is a rare event. Anticoagulation therapy with low-molecular-weight-heparin is standard of care. However, patency cannot be achieved in all cases, increasing the risk for rethrombosis and postthrombotic syndrome.

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The diagnosis of hypothenar hammer syndrome (HHS) should be considered in the case of hand ischemia in people who occupationally or recreationally use the hypothenar region literally as a “hammer”. Routine diagnostics should consist of physical examination including Allen’s test, acral plethysmography and duplex sonography. According to the prevailing opinion angiography remains the «gold standard test» for establishing the diagnosis of HHS.

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Objective: Color duplex sonography (CDS) today is broadly used in the diagnostic workup of patients with suspected cranial or extracranial giant cell arteritis (GCA). This study aimed to determine the prognostic impact of the disease pattern assessed by CDS on the treatment response in GCA.

Methods: This was a retrospective, longitudinal follow-up study of 43 patients who were diagnosed with GCA at our institution between 2002 and 2010.

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Article Synopsis
  • Mitochondrial thioredoxin reductase (Txnrd2) regulates hydrogen peroxide levels and plays a crucial role in tumor growth by impacting Hif-1α signaling, VEGF levels, and tumor vascularization.
  • Tumor cells lacking Txnrd2 showed increased PHD2 levels and reduced Hif-1α signaling, leading to decreased tumor growth due to enhanced JNK activation and changes in the mitochondrial redox state.
  • The study identifies a new regulatory mechanism involving Txnrd2, suggesting that targeting both mitochondrial thioredoxin and glutathione systems could be an effective strategy for cancer therapy.
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