Publications by authors named "P J Huber"
How to Choose an Emollient? Pharmaceutical and sensory attributes for product selection.
Skin Pharmacol Physiol
January 2025
Introduction: Emollients are part of daily body care and have become indispensable therapeutic adjuvants for the treatment of dry skin conditions. Adherence to topical treatments, notably for dry skin conditions, has been reported to be low. The underlying reasons may include insufficient medical and nursing support for product selection, specific product attributes, aspects of product application, and product feel on the skin.
View Article and Find Full Text PDFOver the last decade, the annual Immunorad Conference, held under the joint auspicies of Gustave Roussy (Villejuif, France) and the Weill Cornell Medical College (New-York, USA) has aimed at exploring the latest advancements in the fields of tumor immunology and radiotherapy-immunotherapy combinations for the treatment of cancer. Gathering medical oncologists, radiation oncologists, physicians and researchers with esteemed expertise in these fields, the Immunorad Conference bridges the gap between preclinical outcomes and clinical opportunities. Thus, it paves a promising way toward optimizing radiotherapy-immunotherapy combinations and, from a broader perspective, improving therapeutic strategies for patients with cancer.
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- - The Daya Bay experiment has successfully measured the oscillation amplitude and frequency of reactor antineutrinos over nearly 2,000 days of data, finding significant results about their behavior.
- - They observed over 3.6 million signal candidates using improved selection and calibration methods, leading to a measurement of sin²2θ₁₃ = 0.0759 with a precision that indicates how antineutrinos change states.
- - Combining results from different detection methods at Daya Bay, the overall measurement of sin²2θ₁₃ increased precision to 0.0833±0.0022, representing an 8% improvement in understanding these neutrino properties.
Article Synopsis
- The bioanalytical community traditionally uses blank matrices from preclinical animals for method validation, as required by guidelines, but this practice is increasingly being questioned.
- Despite scientific support for using surrogate matrices instead, regulatory bodies remain hesitant to accept them for most cases, only allowing them for rare situations.
- The European Bioanalysis Forum is advocating for the broader acceptance of surrogate matrices, emphasizing ethical considerations and the need for continued discussions, backed by new experimental data.
Reactive oxygen species (ROS)-mediated immunogenic cell death (ICD) is crucial in radioimmunotherapy by boosting innate antitumor immunity. However, the hypoxic tumor microenvironment (TME) often impedes ROS production, limiting the efficacy of radiotherapy. To tackle this challenge, a combination therapy involving radiotherapy and immune checkpoint blockade (ICB) with anti-programmed death-ligand 1 (PD-L1) has been explored to enhance antitumor effects and reprogram the immunosuppressive TME.
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