Publications by authors named "P J Holmes"
Aims: This expert consensus reviews the reality of primary care clinical management of people with type 2 diabetes (T2D) on non-intensive insulin therapy, with an emphasis on the use of continuous glucose monitoring (CGM) technology for effective care in this participant group. Here, we identify key unmet needs for skills and systems development within this frontline healthcare setting, along with major challenges and opportunities associated with managing these changes effectively.
Methods: The authors participated in two primary care consensus panels held on 28 November 2023 and on 21 May 2024.
A Thematic Analysis of Lived Experiences of Falls in Middle-Aged and Older Adults.
J Frailty Sarcopenia Falls
December 2024
Objectives: Fall-related injuries occur at a similar prevalence rate in middle-aged and older adults and may increase concerns about falling and future falls. No research to date has examined how experiences of falls and related concerns, differ between middle-aged and older fallers. This study aimed to address this using qualitative interviews.
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- Ultrasound microvessel imaging (UMI) shows promise as a noninvasive method to assess microvessel structures in Crohn's disease (CD) by using a quantifiable metric called vessel-length ratio (VLR).
- In a study involving 55 CD patients undergoing surgery, UMI's VLR had a strong correlation (R = 0.80) with pathological inflammation, significantly outperforming color flow imaging (CFI), which had a correlation of R = 0.59.
- UMI not only distinguished between mild and non-mild inflammation more effectively than CFI, but also demonstrated superior performance in a subset of patients with strictures, indicating its potential utility in IBD imaging assessments.
Article Synopsis
- The research aimed to determine how common different visual imagery abilities—aphantasia, hypophantasia, typical imagery, and hyperphantasia—are in a large multinational group of people.
- In the first study, 3,049 participants completed a questionnaire, revealing that 1.2% had aphantasia, 3% had hypophantasia, 89.9% had typical imagery ability, and 5.9% had hyperphantasia.
- A second study combined these results with additional data from previous studies, confirming similar prevalence rates in a larger sample of 9,063 participants, thus providing a comprehensive understanding of visual imagery abilities.
This study examines the sex-specific effects of gestational exposure (days 6-21) to endocrine-disrupting chemicals such as bisphenol A (BPA), diethylhexyl phthalate (DEHP), or their combination on brain monoamine levels that play an important role in regulating behavior. Pregnant Sprague-Dawley rats were orally administered saline, low doses (5 µg/kg BW/day) of BPA or DEHP, and their combination or a high dose (7.5 mg/kg BW/day) of DEHP alone or in combination with BPA during pregnancy.
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