Publications by authors named "P J Godowski"
Article Synopsis
- SIRPα is an immune inhibitory receptor that myeloid cells use to prevent phagocytosis and activation of immune cells, and its potential as a treatment for autoimmune inflammation is being explored.
- Elevated SIRPA levels have been linked to severe cases of inflammatory diseases like rheumatoid arthritis and ulcerative colitis.
- An anti-SIRPα agonistic antibody has shown promise in reducing inflammation by decreasing neutrophil and monocyte infiltration in preclinical models of these conditions.
Article Synopsis
- - A study created knockout mice by disrupting 472 genes related to secreted and membrane proteins to better understand gene functions and their role as drug targets.
- - These knockout mice were systematically tested to observe changes in key areas like embryonic development, metabolism, and various body systems (immune, nervous, cardiovascular).
- - This research represents a unique effort to comprehensively assess the phenotypes of many mouse mutants created through gene-specific methods, which hasn't been done before.
Immune cell-specific expression is one indication of the importance of a gene's role in the immune response. We have compiled a compendium of microarray expression data for virtually all human genes from six key immune cell types and their activated and differentiated states. Immune Response In Silico (IRIS) is a collection of genes that have been selected for specific expression in immune cells.
View Article and Find Full Text PDFNewborns are at increased risk of overwhelming infection, yet the mechanisms underlying this susceptibility are incompletely defined. In this study we report a striking 1- to 3-log decrease in sensitivity of monocytes in human neonatal cord blood, compared with monocytes in adult peripheral blood, to the TNF-alpha-inducing effect of multiple TLR ligands, including bacterial lipopeptides (BLPs), LPS, and the imidazoquinoline compound, imiquimod. In marked contrast, TNF-alpha release in response to R-848, a TLR ligand that is a congener of imiquimod, was equivalent in newborn and adult blood.
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