Publications by authors named "P J Garrett"
Biorthogonal noncanonical amino acid tagging is a labeling strategy that covalently adds a biotin-alkyne (BA) to methionine analogs via a click reaction. When methionine analogs are incorporated into a proteome, enrichment of the BA-labeled proteins allows the detection of newly synthesized proteins (NSP) by mass spectrometry. We previously reported that our direct detection of biotin-containing tags strategy increased protein identifications by enriching for BA-peptides instead of BA-proteins.
View Article and Find Full Text PDFBackground: Patient flow problems, including discharge delay and after-hours discharge, have been a consistently major issue, especially for intensive care units (ICUs). Evidence suggests that discharge delay and after-hours discharge are associated with increased ICU and hospital length of stay, leading to worsened patient outcomes and increased healthcare costs. They can also increase ICU readmission and post-ICU mortality.
View Article and Find Full Text PDFAims: To compare contextual factors influencing discharge practices in three intensive care units (ICUs).
Design: A prospective observational study.
Methods: Data were collected using a discharge process report form (DPRF) between May and September 2023.
Article Synopsis
- Critically ill patients with bloodstream infections (BSIs) who experience hypothermia are at a higher risk of death, but the impact of rewarming rates on their outcomes is not well understood.
- In a study involving 3951 ICU admissions, researchers found that 8.4% of hypothermic patients had temperatures below 34.9°C, and lower temperatures were linked to higher severity of illness and a greater need for organ support.
- The 90-day case-fatality rate was 22.9% overall, with significantly higher rates among those with lower temperatures; faster rewarming was associated with lower mortality rates even after accounting for illness severity and comorbidities.