Publications by authors named "P J Ferris"
Article Synopsis
- - SLPI is a key protein that plays a role in airway immunity by inhibiting harmful enzymatic activity, and it also has anti-inflammatory effects by regulating immune responses through NF-κB inhibition.
- - In lung diseases like COPD and Cystic Fibrosis, SLPI levels can be elevated due to inflammation, but some studies show that COPD patients may have lower SLPI levels, which could weaken airway immunity.
- - Researchers are using a mouse model that mimics features of COPD and CF to study the effects of SLPI by creating a genetically modified mouse (ENaC-Tg/SLPI) to understand how the absence of SLPI influences the progression of these chronic lung diseases.
Volvocine green algae are a model for understanding the evolution of mating types and sexes. They are facultatively sexual, with gametic differentiation occurring in response to nitrogen starvation (-N) in most genera and to sex inducer hormone in . The conserved RWP-RK family transcription factor (TF) MID is encoded by the mating-type locus or male sex-determining region of heterothallic volvocine species and dominantly determines or male gametic differentiation.
View Article and Find Full Text PDFBackground: Interleukin (IL)-18 is a marker of inflammasome activation, and high baseline plasma IL-18 is associated with increased mortality in patients with sepsis-induced ARDS. The aim of this analysis was to determine if simvastatin was associated with benefit in patients with ARDS and high plasma IL-18.
Methods: In this secondary analysis of the HARP-2 study, we compared 28-day mortality and response to simvastatin according to baseline plasma IL-18 using cox proportional hazards analysis.
The evolution of germ-soma cellular differentiation represents a key step in the evolution of multicellular individuality. Volvox carteri and its relatives, the volvocine green algae, provide a model system for studying the evolution of cellular differentiation. In V.
View Article and Find Full Text PDFAcute kidney injury (AKI) is a common syndrome that is associated with significant mortality and cost. The Quality Improvement AKI Collaborative at Salford Royal Foundation Trust was established to review and improve both the recognition and management of AKI. This was a whole-system intervention to tackle AKI implemented as an alternative to employing separate AKI nurses.
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