Publications by authors named "P J Fagenholz"
Objective: To investigate the incidence and management of pancreatic fistula and fluid collections (FC) after distal pancreatectomy (DP).
Summary Background Data: Pancreatic fistula and FC are common after DP. The relationship between pancreatic fistula, FC, and surgical drain placement remains unclear.
Article Synopsis
- Acute pancreatitis is a significant indicator in patients with intraductal papillary mucinous neoplasms (IPMNs), as about 19.2% of patients showed this symptom, often leading to diagnosis.
- Acute pancreatitis is linked to a higher risk of high-grade dysplasia (2.07 times more likely) and certain types of IPMNs, but it is less associated with invasive cancer (0.62 times less likely).
- After surgical resection, 9% of patients with a history of pancreatitis experienced recurrent episodes, compared to only 0.9% in those without prior pancreatitis.
Pancreatic cancer remains a high unmet medical need. Understanding the interactions between stroma and cancer cells in this disease may unveil new opportunities for therapeutic intervention.
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- Pancreas divisum (PD) is a common birth defect of the pancreas, but the genetic factors behind it are still unclear, prompting a genome-wide study to find potential genetic links.
- Researchers analyzed data from 13,940 participants, identifying a significant genetic locus on chromosome 3q29 associated with PD, specifically linked to two genes related to cellular functions.
- The study not only established a genetic link to PD but also identified potential regulatory genes that might influence pancreatic development, which could aid in better understanding and treating related pancreatic conditions.
Objective: To describe the long-term natural history of branch duct intraductal papillary mucinous neoplasm (BD-IPMN).
Background: The BD-IPMN is a known precursor of pancreatic cancer, yet its long-term natural history is largely unknown.
Methods: We retrospectively reviewed patients with BD-IPMN who were followed at the Massachusetts General Hospital for at least 10 years without surgical intervention.