Publications by authors named "P J Dunn"
The ageing process involves a gradual decline of chromosome integrity throughout an organism's lifespan. Telomeres are protective DNA-protein complexes that cap the ends of linear chromosomes in eukaryotic organisms. Telomeric DNA consists of long stretches of short "TTAGGG" repeats that are conserved across most eukaryotes including humans.
View Article and Find Full Text PDFUnder recent reforms to the National Health Service (NHS) in England, NHS organizations have been given new objectives to contribute to social and economic development. Health systems in other high-income countries are pursuing related approaches. This paper analyses national policy documents to understand the framing of the NHS's new policy priorities on social and economic development.
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- The study examined the link between Personal Activity Intelligence (PAI) scores and coronary heart disease (CHD) in a large group of healthy adults in Norway, emphasizing the impact of physical activity intensity on CHD risk.
- Researchers analyzed data from over 40,000 participants, finding that those with higher PAI scores (51-99 and ≥ 100) had a significantly lower risk of experiencing fatal and non-fatal CHD during a median follow-up of 13.1 years.
- The inclusion of PAI in traditional risk assessments improved the ability to classify individuals' CHD risk, highlighting that a PAI score above 50 is notably protective against CHD.
Avian reovirus-infected hens shed virus heavily at 2-3 days post-inoculation.Shedding became minimal after 5-7 days post-inoculation.ARV variants offered 100% protection in hens upon subsequent infections.
View Article and Find Full Text PDFMethodological approaches in 16S sequencing of female reproductive tract in fertility patients: a review.
J Assist Reprod Genet
October 2024
Background: The female genital tract microbiome has become a particular area of interest in improving assisted reproductive technology (ART) outcomes with the emergence of next-generation sequencing (NGS) technology. However, NGS assessment of microbiomes currently lacks uniformity and poses significant challenges for accurate and precise bacterial population representation.
Objective: As multiple NGS platforms and assays have been developed in recent years for microbiome investigation-including the advent of long-read sequencing technologies-this work aimed to identify current trends and practices undertaken in female genital tract microbiome investigations.